High MPV thus appears correlated with myeloproliferative disease or thalassemia and low MPV, with cytotoxic drugs or marrow hypoplasia. All had sepsis, splenomegaly, aplastic anemia, chronic renal failure, or a disease being treated with myelosuppressive drugs. The purpose of the present study was to compare MPV in prediabetic and normoglycemic subjects, and to evaluate the relationship between MPV and fasting plasma glucose (FPG) levels in these two groups. However, the relationship between MPV and prediabetes is poorly understood. High MPV is associated with cancer, but keep in mind this isn’t a diagnosis. Bone marrow releases platelets, and a high MPV means the marrow is producing platelets too quickly. 52 patients had an MPV that was inappropriately low for the platelet count (high, normal, or low). In diabetic patients, MPV is higher when compared with normal subjects. A high MPV means that your platelets are larger than the population average, and your body may be producing too many platelets. Platelets are small blood cells that play an essential role in. Seven patients had high MPV and high platelet count: causes included myeloproliferative disorders, inflammation, iron deficiency, and splenectomy, 25 patients had high platelet counts and normal MPV: the causes were inflammation, infection, sickle cell anemia, iron deficiency, or chronic myelogenous leukemia. An MPV measures the average size of platelets and its closely related to the platelet count. There are numerous reasons behind this abnormal. 15 patients had high MPV and normal platelet count: 12 had heterozygous thalassemia, and three had iron deficiency. MPV level may also rise due to its destruction and should be taken care of as well. 11 patients had high MPV and low platelet count: all had hyperdestructive causes.
Addition of a second variable, mean platelet volume (MPV), to the routine blood count allows classification of patients into 9 categories: high, low, or normal MPV, and high, low or normal platelet count. Classification of platelet disorders has been based on the platelet count. found that high MPV can be useful in identifying patients with newly diagnosed breast cancer patients and is likely to present with distant metastasis in the.